An F.B.I. agent is forced to work with an institutionalized scientist and his son in order to rationalize a brewing storm of unexplained phenomena.

The Fringe Division investigates cases relating to fringe science, ranging from transhumanist experiments gone wrong to the prospect of a destructive technological singularity to a possible collision of two parallel universes.

The Fringe Division's work often intersects with advanced biotechnology developed by a company called Massive Dynamic, founded by Walter's former partner, Dr. William Bell (Leonard Nimoy), and run by their common friend, Nina Sharp (Blair Brown).