After her husband leaves her, young mother of two Miriam "Midge" Maisel discovers that she has a talent for stand-up comedy. Could this be her calling?

Set in 1950s Manhattan, The Marvelous Mrs. Maisel is a 60-minute dramedy that centers on Miriam "Midge" Maisel, a sunny, energetic, sharp Jewish woman who had her life mapped out: go to college, find a husband, have kids, and throw the best Yom Kippur breakfasts in town. Soon enough, she finds herself exactly where she had hoped to be, living happily with her husband and two children on the Upper West Side.

A woman of her time, Midge is a cheerleader wife of a man who dreams of a stand-up comedy career, but her perfect life is upended when her husband suddenly leaves her for another woman. Utterly unprepared, Midge is left with no choice but to reevaluate her life. When she accidentally stumbles onto the stage at a nightclub, she discovers her own comedic skills and decides to use this newfound talent to help her reinvent her life. The series follows the trajectory of Midge's journey as she pursues a career in the male-dominated stand-up comedy profession, and it transforms from uptown society matron to East Village club performer.