After an experimental bioweapon is released, turning thousands into zombie-like creatures, it's up to a rag-tag group of survivors to stop the infected and those behind its release.

The movie follows a group of survivors trying to escape a zombies outbreak caused by a government experiment gone wrong. The film stars Rose McGowan, Freddy Rodriguez and Bruce Willis. The film is a part of the double feature film Grindhouse, along with Quentin Tarantino's Death Proof. Along with its horror elements, the film also features action, comedy and a B-movie aesthetic.