Smiling Friends follows the employees of a small company dedicated to bringing happiness to a bizarre yet colorful world.

Smiling Friends Inc. is a small company whose main purpose is to bring happiness and make people smile. The series follows the day-to-day lives and misadventures of its representatives, the lazy, cynical Charlie, and the cheerful, optimistic Pim, as they try to cheer up and comfort the troubled people who call their company's hotline.

They receive seemingly simple requests but the jobs turn out to be more complicated than they seem, making it difficult to bring happiness to the world.