Dr. Richard Kimble, unjustly accused of murdering his wife, must find the real killer while being the target of a nationwide manhunt led by a seasoned U.S. Marshal.

Wrongfully accused of murdering his wife, Richard Kimble (Harrison Ford) escapes from the law in an attempt to find her killer and clear his name. Pursuing him is a team of U.S. marshals led by Deputy Samuel Gerard (Tommy Lee Jones), a determined detective who will not rest until Richard is captured.

As Richard leads the team through a series of intricate chases, he discovers the secrets behind his wife's death and struggles to expose the killer before it is too late.