Affable hillbillies Tucker and Dale are on vacation at their dilapidated mountain cabin when they are mistaken for murderers by a group of preppy college students.

Dale (Tyler Labine) and Tucker (Alan Tudyk) are checking out their newly acquired "summer home" (read: dilapidated cabin) when they save the life of a gorgeous college student (Katrina Bowden) who's camping in the woods with some friends.

When a series of misunderstandings leads to Dale and Tucker being labeled psycho killers by the vacationing students, the situation takes a sudden and ghastly turn for the worst.