A cocaine shipment makes its way to Europe, starting from the moment a powerful cartel of Italian criminals decides to buy it, to its journeys through Mexico, to its shipment across the Atlantic Ocean.

"ZeroZeroZero" follows a gripping international cocaine shipment as it weaves through the criminal underbelly of three continents. The Lynwood family, a powerful American dynasty, is entrusted with transporting the cargo from Mexico to Italy, setting the stage for a high-stakes journey fraught with peril. Simultaneously, Don Minu, an aging Italian mafia boss, seeks to maintain control amid changing crime dynamics.

In Mexico, Manuel Contreras, a soldier, spirals into the drug trade's darkness after a traumatic incident. As their paths converge, a complex web of power, morality, and brutality emerges. The series explores the global drug trade's far-reaching consequences, using intricate storytelling and cinematic prowess to unravel a world of violence, suspense, and moral ambiguity.