Fifteen years after murdering his sister on Halloween night 1963, Michael Myers escapes from a mental hospital and returns to the small town of Haddonfield, Illinois to kill again.

The year is 1963, the night: Halloween. Police are called to 43 Lampkin Ln. only to discover that 15-year-old Judith Myers has been stabbed to death by her 6-year-old brother, Michael. After being institutionalized for 15 years, Myers breaks out on the night before Halloween.

No one knows, nor wants to find out, what will happen on October 31st 1978, besides Myers' psychiatrist, Dr. Loomis. He knows Michael is coming back to Haddonfield, but by the time the town realizes it, it'll be too late for many people.