While a judge's anti-drug campaign leads him to his own daughter, a DEA agent targets a trafficker's wife, and a policeman fights corruption.

A patchwork of stories about various factions of the drug trade, including dealers, abusers and the law enforcement officials who pursue them. Mexican policeman Javier Rodriguez works on and around the border with his close friend and fellow policeman Manolo Sanchez, under Mexico's number one crime fighter, General Salazar. Confronted with temptations of power and money, Javier resists them but finds himself--and Manolo--caught in a web of corruption that leads to an untenable situation.

Back in the U.S., Ohio State Supreme Court Justice Robert Wakefield is named by the president as the new antidrug czar. Collecting information, the uncompromising and conservative Wakefield prepares to supervise the country's task forces and partner them with Mexico's. But, at home, he and his wife Barbara must deal with their increasingly drug-addicted teenage daughter Caroline.