An oddball group of cops, criminals, tourists and teens converge on a Georgia forest where a huge black bear goes on a murderous rampage after unintentionally ingesting cocaine.

"Cocaine Bear" tells the incredible true story of Bunny, a young drug smuggler who accidentally drops a duffel bag full of cocaine into the woods of Georgia. Unbeknownst to Bunny, her misstep attracts the attention of a bear, which consumes the entire stash. As the drugs take hold of the bear, it goes on a wild and unpredictable rampage.

Bunny finds herself entangled with a park ranger named Hank, who is determined to contain the chaos caused by the cocaine-fueled bear. Together, they embark on a madcap adventure, navigating the dangers of the wilderness and evading the clutches of a drug lord and a bumbling FBI agent.